The Science and Technology Parks have been established as a global phenomenon, due to economic and social development achieved by the countries to implement this system. The aim of this paper is to describe the origin and evolution of the more representative Science and Technology Parks around the world, the role of the Triple Helix model in its development and the viability of these initiatives in Colombia. To obtain this information a literature review was conducted in articles and books published between 2000 and 2015, along with information from national and international policies and own data obtained from surveys. A definition of Science and Technology Park is proposed: an institution with real space with tax benefits where universities and companies are installed to provide specialized services and to develop innovative processes by making use of governmental policies on science and technology. Due to the mandatory interaction between university industry and government, Science and Technology Parks are an optimal setting for the Triple Helix model application. In the Colombian Caribbean region there are conditions for implementing projects of parks because exist needs in the companies, capacities in the universities and appropriate policies about science, technology and innovation; however great efforts are required by all the stakeholders to get the implementation of sustainable models.