Objective: to assess the adherence to home respiratory therapy plans in patients with chronic diseases from a home care program whose treatments include respiratory therapy practice in the city of Santiago de Cali, Colombia. This study focused mainly on the patients affiliated to the home care program of the SISANAR health care providing institution. Methodology: an observational, descriptive and cross-sectional study was conducted. The studied population consisted of 83 adults aged 45 to 85 with chronic pathologies which did not alter cognitive functions. These patients were part of the respiratory therapy program of the SISANAR health care providing institution. An interview geared at both patients and primary caregivers was designed. Results: the behavior between the variables analyzed was not parallel for both variables. This was due either to factors such as affiliation type (which is the case of the home care program vs. the General System for Social Security in Health), or to a behavior reflecting a difference in the number of sessions per month and the activities recorded in the home care plan. Discussion: this study found that home plans show that adherence is effective but highly dependent on both compliance with activities and the initial management provided by the patients' social security system.