The rights of homosexuals and same-sex couples are currently the subject of debate on the public stage and in courtrooms around the world. This debate is often colored by prejudice and misconceptions regarding homosexuality, particularly in low- and middle-income countries. This study investigates the opinions of Colombian women about same-sex couples' rights and women's attitudes toward a homosexual child (maternal acceptance). Using a nationally representative data set, we find that that younger, wealthier, and more educated Colombian women are more likely to support their homosexual child and approve of same-sex couples' rights, while women with misconceptions regarding the human immunodeficiency virus and homosexuality are less likely to be supportive of a homosexual child and less likely to approve of same-sex couples' rights. The rights of homosexuals and same-sex couples are currently the subject of debate on the public stage and in courtrooms around the world (Becker, 2012; van den Akker, van der Ploeg, & Scheepers, 2013). This debate is often colored by prejudice and misconceptions and, more often than not, there is no credible scientific evidence to support or undermine an argument (Cianelli, Ferrer, & McElmurry, 2008; Herek & McLemore, 2013). This situation raises several issues because decisions that affect the rights of homosexual individuals and same-sex couples are taken without a deep understanding of current evidence. In addition to the importance of improving the use and availability of evidence to inform policy, it is also crucial to explore public opinion on homosexuality and on same-sex couples' rights to understand how the general population might respond to a certain policy or intervention (Brewer, 2014; Powell, Quadlin, & Pizmony-Levy, 2015). Of particular concern is the situation of homosexuals living in low- and middle-income countries with high levels of inequality, where the homosexual population is generally more vulnerable and exposed to negative attitudes compared with high-income countries (Andersen & Fetner, 2008).