The objective of this article is to examine the influence of internal and external (environmental) factors on intrapreneurship in the Spanish context, considering differences among regions. Methodologically, the study applies logistic regression and uses data from the Spanish Global Entrepreneurship Monitor for the year 2011. The main findings of the research show through a double conceptual framework (resource-based theory and institutional economics) the direct effect of both internal factors – opportunity recognition and social capital – and environmental factors – fear of failure and education – on intrapreneurship. In addition, the role of fear of failure is reinforced as it has the indirect (moderating) effect; this effect is particularly relevant in lower income regions. The study contributes both theoretically (developing literature and provoking discussion in the field of intrapreneurship) and empirically (providing useful insights for the design of governmental policies for fostering entrepreneurial activities within firms).