Background: Colombia has been incriminated in Transplant Tourism for the past years. Historically, organ transplantation was regulated in Colombia by two broad and general laws (Nº9 from 1979 and Nº73 from 1988). The lack of control and specific regulation facilitated the development of unethical practices; so, Colombia was considered a top “exporter of organs” for almost 20 years. On 2004, the Colombian Government started to oversee and control the donation and allocation of organs issuing two laws that considered this practice a crime with legal and financial consequences. Finally, a 2010 declaration of the Council of State and the new policy of the National Institute of Health (NIH) about Organ Transplantation to foreigners non-Colombian residents published in 2011, would close up the door to the Transplant Tourism in this country. Aim: To investigate and report the direct impact of new Colombian policies against Transplant Tourism and Organ Trafficking on clinical practice. Materials and methods: A 6 year retrospective study of National and International Data Reports on organ transplantation to foreigners non-Colombian residents after the implementation of new laws and government regulations. Results: Since the issue of the Executive Order Nº2493/2004 the Colombian Government though the NIH began to control the donation, allocation and transplantation of organs across the country. Also, with the law Nº 919/2004 issued by the Congress of the Republic of Colombia, the trafficking and commercialization of organs was defined, penalized and criminalized. Beside those new laws, in April 2010 the Colombian Council of State wrote a declaration by which it orders to the NIH to update the policies about organ transplantation to foreigners non-Colombian residents. After implementation of these laws and the new policies, the rates of transplanted grafts to foreigners non-Colombian residents significantly decreased from 16.5% in 2005 to 0.7% in 2011 (Graph 1).Figure: [Annual % of transplants to foreigners in Colombia]Conclusion: Despite the difficulties, after six years of struggling against Transplant Tourism, the Colombian transplantation system finally meets the recommendations from the 2008 “Istanbul Summit and Declaration” and the 2010 World Health Organization “Madrid Resolution”. With the implementation of new legislations by the Colombian Government and the creation of the National Donation and Transplantation Network by the NIH, the rate of transplants of foreigners non-residents dropped to less than 1%. The few transplants to foreigners non-Colombian residents that currently continue to occur meet the law requirements and depend on the national waiting list. By this, Colombia shows that it is strongly committed to ensuring that organ transplants are carried out within the law and respect the universal principles of equity, equality and justice.