<h3>Background</h3> Rheumatoid arthritis (RA) is a disease that in most cases is associated with disability and loss of earning capacity. There is a lack of information about occupation of rheumatoid arthritis patients in Colombia, being this field important in order to improve clinical and social outcomes for them. Also is not studied correlation with disease activity and disability. <h3>Objectives</h3> The aim of this study was to describe the occupation of a cohort of RA patients and its possible relationship with disease activity and functionality in a specialized center in Colombia. <h3>Methods</h3> A descriptive cross sectional study was realized. A revision of medical records of a cohort of RA patients was performed, including occupational therapy records. Each patient was evaluated for DAS28, HAQ and OPHI2 (Occupational Performance History Interview 2). Descriptive epidemiology was done, percentages and averages were calculated; Pearson9s statistics was used for by-variated analysis. <h3>Results</h3> Of the 139 RA patients included, 27 (19.4%) were men and 112 (80.6%) women. Mean age 56.1±9 years, for women 55.9 years and for men 57 years. Average DAS 28 for all patients 3.01, (2.5 for women and 2.63 for men), average HAQ were 0.36 (0.43 for women and 0.39 for men). Most frequent occupations (percentage, DAS 28 and HAQ means) were: low impact work 57 (41%, 2.6, 0.44); domestic work 36 (25.9%, 2.43, 0.37); administrative work 31 (22.3%, 2.13, 1.00). It was not established correlation between occupation and disease activity or functionality. <h3>Conclusions</h3> Interestingly most active RA patients were kindergarten teachers with an average moderate disease activity, followed by sewing operators. Less active disease scores were found on floriculture workers. In regard of functional status, sewing operators had higher scores followed by housekeepers; but in general for all types of occupations HAQ scores were low. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4775