This paper presents the results of evaluating the susceptibility and risk analysis of bank erosion in rivers by evaluating the exposure of banks to shear stress and velocity combined with hydrologic and geomorphologic variables. A 75-km sector of the Meta River was taken as a case study for this research by conducting 2D numerical hydrodynamic and morphologic modeling with MIKE-21C. The study integrated hydrographs for different exceedance probabilities, bank resistance and bank variability maps, shear stress, and velocity and bed level change to achieve a complete analysis to determine the susceptibility and risk of bank erosion. A time exposure analysis was conducted to determine the percentage of time that velocity and shear stress are higher than threshold values for different soil materials. These results were analyzed conjointly with the river's bank resistance and the probabilities associated with different hydrographs. It was found that specific geomorphologic resistances (low, medium, or high) have different susceptibilities depending on the hydrodynamic conditions acting on the bank and the time exposure and probability of occurrence. These results allowed identifying areas with high risk of bank erosion and predicting potential river bank mobility under different hydrological scenarios.