Densities of four binary mixtures formed by an isomer of chlorobutane (1-chlorobutane, 2-chlorobutane, 1-chloro-2-methylpropane, or 2-chloro-2-methylpropane) and methyl tert-butyl ether have been measured in the temperature range 283.15 K–313.15 K; from these densities the corresponding excess volumes have been obtained and correlated. The isothermal vapor–liquid equilibria have been also studied at T = 288.15, 298.15, and 308.15 K, and the experimental data have been satisfactorily checked for thermodynamic consistency using the method of Van Ness. The isothermal vapor–liquid equilibria data have been correlated using the Wilson equation, and excess Gibbs energies have been calculated. We have employed this experimental information to check the reliability of the predicted densities and vapor–liquid equilibria of the volume translated Peng–Robinson group contribution equation of state (VTPR model) by comparing the experimental results with the corresponding predictions. The predictions of both properties can be considered as satisfactory.