The solubilities of amiodarone HCl (AMDH) in binary mixtures of ethanol + water and N-methyl pyrrolidone (NMP) + water at (293.2, 298.2, 303.2, 308.2, and 313.2) K are reported. In the ethanol + water system the maximum solubility of AMDH was observed at 313.2 K and an ethanol mass fraction of 0.76. The combination of the Jouyban–Acree model and van't Hoff equation was used to predict the solubility of AMDH in the mixed solvents at different temperatures. A mean relative deviation of 12.2 % was obtained for the correlated data. The standard enthalpy, entropy ,and Gibbs energy changes of solutions for AMDH in ethanol + water and NMP + water mixtures were calculated from the measured solubility data using the modified version of the van't Hoff equation.