ImpactU Versión 3.11.2 Última actualización: Interfaz de Usuario: 16/10/2025 Base de Datos: 29/08/2025 Hecho en Colombia
4-N-ARYL(BENZYL)AMINO-4-HETEROARYL-1-BUTENES AS BUILDING BLOCKS IN HETEROCYCLIC SYNTHESIS. 2. SYNTHESIS OF NEW TETRAHYDRO-2-BENZAZEPINE DERIVATIVES AND RELATED COMPOUNDS CONTAINING A PYRIDINE RING
Chemical transformations of the aminobutenes (1,2) were studied.Their allyl cationic intramolecular cyclisation led to the preparation of new tetrahydro-2-benzazepines containing a pyridine ring (3,4).The acylation and oxidation reactions of these aminobutenes gave several amides (5,6,8) and nitrone (7a), which was converted into the 6-phenyl-2-(3-pyridyl)-7-oxa-l-azabicyclo[2.2.1]heptane (9a).
Tópico:
Synthesis and pharmacology of benzodiazepine derivatives
