Allogeneic hematopoietic stem cell transplantation (HSCT) is an increasingly common treatment for malignant and non-malignant hematologic diseases. The major limitation to the realization of this type of transplant is access to an HLA-identical donor within the family. Only 30% of patients referred for transplantation will have an appropriate RD; using HLA-identical URD is an alternative for these patients. The aim of this study is to describe the first experience in Colombia with this type of transplant. Observational case series. From July 1, 2011, have been 89 searches have been started. The most frequent diagnosis acute leukemia (47 ALL, 25 AML). Since there isn't a national donors registry, searches were performed through NMDP. 26 matched-URD (10/10 or 9/10) were found (29.81%) and 14 transplants have been performed. 8 patients with an URD died before transplantation, 2 lost indication and 2 transplants are waiting. The median time from the start of the search to finding the donor was 52 days (range 28-240) and once the donor was located it took a median of 67 days (range 36-94) to the infusion. Transplanted patients were 7 males/7 females, mean age 30 years (2-59), 9 had AML, 3 ALL and 2 SAA. Most leukemias were in first CR (10). Donors were on the majority young (median 37 years; range 21-55), males (8), CMV positive. PBSC were use in 10 cases. Busulfan-Fludarabine-ATG conditioning regimen was used for leukemia. GVHD prophylaxis consisted of Cs-MTX. Survival: With a median follow up of 5.83 months (range: 0.86-17.9), 12 of the 14 patients are alive and in remission of their disease (OS 85.7%). One patient died from aGVHD complications and the other due to idiopathic pneumonitis. 2 of the 14 had grade III -IV aGVHD . Allogeneic DNF is possible in Colombia and results are the same that would be expected for a similar population with RD. Low rates of success in finding an URD for our Hispanic patients reflects the fact that they represent a minority in world registries and highlight the need for the creation of local registries.