Abstract We prepared a new nonionic surfactant, 8 , in which the n ‐dodecyl chain is attached at the C‐3 carbon of the D ‐glucose‐based glucopyranose moiety by the linkage Z=−O‐(α‐PP‐O) n with −O‐(α‐PP‐O) n being a commercial poly‐(α‐propyloxy) oligomeric mixture (with average ñ =6). This amphiphilic behavior study showed that, when compared to the reference compound 3‐O‐dodecyl‐ D ‐glucopyranose (Z=O), compound 8 exhibits (i) a water solubility that is 100‐fold higher, (ii) a hydrophilic‐lipophilic balance value increase from 8.5 to 12.6 units, and (iii) a slighly lower critical micelle concentration.