<h3>Background</h3> Late-onset systemic lupus erythematosus (LOSLE) is a disease-specific subgroup, which begins clinically after 50 years of age. LOSLE may have unusual clinical and laboratory characteristics, which may delay the diagnosis and timely treatment of the disease. <h3>Objectives</h3> To determine the clinical, serological and immunogenetic (HLA-DRB1) differences among patients with LOSLE versus SLE starting at younger ages. <h3>Methods</h3> Cross-sectional study in a Colombian population of individuals with SLE according to ACR criteria. Clinical and serological variables were analyzed in 98 patients with LOSLE and 72 patients with early-onset lupus. The HLA-DRB1 genotyping was analyzed in 62 samples from patients with LOSLE and 179 samples from patients without autoimmune disease. <h3>Results</h3> Table 1 show the statistically significant clinical and laboratory findings between patients LOSLE vs. early-onset SLE. In patients with LOSLE, the HLA DR17 (DR3) was found more frequently compared to individuals without autoimmune disease (OR 3.81 - 95% CI 1.47 to 10.59) (p=0.0016). <h3>Conclusions</h3> In the Colombian population with SLE, there is a probable association between various clinical and serological features, which differentiate the beginning of disease among patients with late-onset SLE vs. early-onset SLE. <h3>References</h3> Appenzeller S, Pereira DA, Costallat LT. Greater accrual damage in late-onset systemic lupus erythematosus: a long-term follow-up study. Lupus. 2008 Nov;17(11):1023-8. Boddaert J, Huong DL, Amoura Z, Wechsler B, Godeau P, Piette JC. Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature. Medicine (Baltimore). 2004 Nov;83(6):348-59. Lalani S, Pope J, de Leon F, Peschken C; Members of CaNIOS/1000 Faces of Lupus. Clinical features and prognosis of late-onset systemic lupus erythematosus: results from the 1000 faces of lupus study. J Rheumatol. 2010 Jan;37(1):38-44. Padovan M, Govoni M, Castellino G, Rizzo N, Fotinidi M, Trotta F. Late onset systemic lupus erythematosus: no substantial differences using different cut-off ages. Rheumatol Int. 2007 Jun;27(8):735-41. <h3>Disclosure of Interest</h3> None Declared