Introduccion: el fibroma osificante periferico es un tumor de crecimiento focal, que se localiza usualmente en la encia y frecuentemente es recidivante. Clinicamente se puede confundir con el granuloma periferico de celulas gigantes, fibroma de celulas gigantes, fibroma simple y con el granuloma telangectasico, por lo que siempre amerita diagnostico histologico. Caso clinico: paciente femenina de 49 anos de edad, que consulto por presentar recidiva de una lesion en la cavidad oral. Presentaba inconformidad estetica y funcional por la tumoracion en zona premolar izquierda, con evolucion de dos anos. Se realizo extraccion quirurgica. El estudio histopatologico confirmo diagnostico de fibroma osificante periferico. Conclusion: la intervencion quirurgica debe incluir la escision completa del tumor para reducir la posibilidad de recidiva. Rev.cienc.biomed. 2014;5(1):130-133 PALABRAS CLAVE Fibroma osificante; Enfermedades de la boca; Medicina oral. SUMMARY Introduction : Peripheral ossifying fibroma is a focal growth tumor which is usually located in the gum and is frequently recurrent. Clinically, it could be confused with peripheral giant cell granuloma, giant cell fibroma, simple fibroma and telangiecticum granuloma, consequently a histological diagnosis is always necessary. Clinical case : A 49 years old female patient, who consulted for recurrence injury in oral cavity; who presented esthetic and functional dissatisfaction because of the tumor, which was located in the maxillary left premolar region, and with two years of evolution. The injury was surgically removed. The diagnosis of peripheral ossifying fibroma was confirmed by histopathological study. Conclusion : Surgical procedure must include a complete surgical excision of the tumor in order to reduce the risk of relapse. Rev.cienc.biomed.2014;5(1):130-133 KEYWORDS Fibroma ossifying; Mouth diseases; Oral medicine.