The ethnobotany looks at how different human groups interact with the vegetation. The aim of the job was to conduct a study of traditional community and the relationship of use of plant species in Settlement Pedra Suada, Cachoeira Grande, Maranhao, Brazil. The methodology used was the application of semi-structured questionnaires. Women accounted for 58% of the public identified as having knowledge about use of plants in the settlement. The main activity carried out among respondents was farmer (a), with 64% of the total described occupation. 81 species were recorded, which were identified 42 plant families and one has not been identified. Lamiaceae family is the most represented species, 10 (12,35%), followed by Fabaceae 6 (7,41%), Rubiaceae 5 (6, 18 %), Apocynaceae, Anacardiaceae 4 (4,94%), Arecaceae, Amaranthaceae, Malvaceae, Euphorbiaceae and Bignoniaceae 3 (3,7%), and another 32 families with 37 species (45,68%). Among the species reported 55,6% had the use described as exclusively medical and 43,2% for multiple use. Among the diseases mentioned by the respondents of the digestive tract are the most cited with treatment using plants, associated with local knowledge, representing 18,6%. The form of manipulation of medicinal most used among respondents was in the form of tea (56,9%). The record local knowledge about the uses of native plants in the region will allow the rescue and dissemination of that knowledge.