Introduccion: el Granuloma Actinico de O’Brien (GAO), tambien denominado Granuloma Elastolitico Anular de Celulas Gigantes, fue descrito inicialmente en 1975. Se considera una dermatosis infrecuente, caracterizada por papulas anulares y eritematosas que se distribuyen en areas corporales expuestas a la luz solar. Reporte de caso: paciente femenina de 52 anos de edad, con cuadro clinico de aproximadamente 24 meses de evolucion, caracterizado por dermatosis diseminada, simetrica, con compromiso de miembros superiores, torax superior y muslo, en forma de placas anulares. No se documento exposicion solar mayor a la habitual. Se administro dipropionato de betametasona al 0.05 % de forma topica acompanado de protector solar, con adecuada mejoria de la entidad. Conclusion: el GAO es una rara afeccion de la piel, de patogenesis poco clara, que se desarrolla en areas expuestas al sol, con la radiacion solar es factor predisponente. Tiene como teoria mas aceptada para su instalacion, el desarrollo de respuesta inmune mediada por celulas a determinantes antigenicos, presentes en las fibras elasticas actinicamente alteradas. Los hallazgos encontrados en la paciente concuerdan con los reportados. Rev.cienc.biomed. 2014;5(2):336-340. PALABRAS CLAVE Granuloma; Dermatosis; Granuloma de O’Brien. SUMMARY Introduction: the O’Brien’s Actinic Granuloma (OAG), also known as Annular Elastolytic Giant-Cell Granuloma, was described initially in 1975. It is an infrequent dermatosis that is characterized by annular plaques with erythematous margins that are distributed in sun-exposed areas of the body. Case report: 52-year-old female patient with symptomatology of 24 months of evolution, characterized by scattered and symmetric dermatosis, with commitment of superior members, superior chest and thigh, in form of annular plaques. It was not documented sun exposition higher to the habitual. Betamethasone dipropionate 0.05% was use topically accompanied of sunscreen with adequate improvement of the disease. Conclusion: the OAG is a rare skin lesion, of unknown pathogenesis, that is developed in sun-exposed areas. It has as the most widely accepted theory for its appearance, the development of immune response by cells to antigenic determinants, present in the elastic fibers with actinic alteration. The findings of the patient were concordant with the previously reported. Rev.cienc.biomed. 2014;5(2):336-340. KEYWORDS Granuloma; Dermatoses; O’Brien’s granuloma;