Introduccion: la mordedura por serpiente del genero Bothrops es importante causa de accidente ofidico en Colombia, con elevada morbilidad y mortalidad. Caso clinico: se presenta caso de mordedura de serpiente Bothrops asper , que fue clasificado como grado leve de envenenamiento al ingresar al centro hospitalario. Fue manejado con suero antiofidico a dosis inferior a la recomendada, con progresion del cuadro de envenenamiento. Se realizaron ajustes en la dosis y se alcanzo recuperacion total en cinco dias. Conclusion: los sueros antiofidicos, denominados tambien antivenenos, son la piedra angular del tratamiento para minimizar el dano tisular local y las complicaciones sistemicas. Rev.cienc.biomed. 2013;4(2):353-357 PALABRAS CLAVE Mordeduras de serpientes; Venenos de serpiente; Bothrops. SUMMARY Introduction: The snake bite of the genus Bothrops is an important cause of ophidic accident in Colombia, with high morbidity and mortality. Clinical case: A case of bite by the snake Bothrops Asper , which was classified as mild grade of poisoning at the entrance of the hospital center is presented. It was managed with antiophidic serum in doses lower than the recommended one, with progression of the symptoms of poisoning. Adjustments in the doses were done and total recovery was reached in five days. Conclusions : Antiophidic serums, named also antivenins, are the cornerstone of the treatment to minimize the local tissue damage and the systemic complications. Rev.cienc.biomed. 2013;4(2):353-357 KEYWORDS Snake Bites; Snake Venoms; Bothrops.