Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors. Approximately 40% to 80% of cancer patients undergoing active treatment suffer from CRF. Exercise improves overall quality of life and CRF; however, the specific effects of the training modalities are not well understood. Purpose: This study aimed to determine the effects of health professional supervised multimodal exercise interventions on cancer-related fatigue through a systematic review and meta-analysis.