Introduccion: la trombosis del seno longitudinal superior es responsable del 0.5% de los casos de accidentes cerebrovasculares en el mundo. Tiene una mortalidad del 10% y afecta mas a mujeres jovenes entre la cuarta y la quinta decada de la vida. Caso clinico : paciente de sexo masculino, sin antecedentes de importancia, previamente sano, que consulto por cefalea. Mediante TAC cerebral simple y panangiografia cerebral se diagnostico trombosis del seno longitudinal superior. Se realizo tratamiento con anticoagulante, presentando evolucion favorable. Conclusion: la trombosis del seno longitudinal superior continua siendo de diagnostico dificil debido al caracter banal de su presentacion clinica. Se necesita tener una alta sospecha para alcanzar el diagnostico. Rev.cienc.biomed. 2014;5(1):116-122 PALABRAS CLAVE Venas cerebrales; Trombosis intracraneal; Angiografia cerebral; Neurocirugia. SUMMARY Introduction : thrombosis of superior sagittal sinus is responsible for 0.5% of stroke cases in the world. Stroke has a mortality rate of 10% and it is more frequent in women between the fourth and fifth decade. Clinical case report : we present a case report of a male patient, no previous medical history, which consults with headache. Computed tomography of the brain without contrast and pan-angiography allowed to realize the diagnosis of thrombosis of superior sagittal sinus. Treatment with anticoagulants, was started with a satisfactory outcome. Conclusion : thrombosis of superior sagittal sinus is a difficult diagnosis. It is necessary a high suspicion to reach the diagnosis. Rev.cienc.biomed. 2014;5(1):116-122 KEYWORDS Cerebral veins; Intracranial thrombosis; Cerebral angiography; Neurosurgery