Introduccion: multiples son las entidades transmitidas por garrapatas, una de ellas es la babesiosis, entidad producida por especies de hemoparasitos que producen en el huesped humano hemolisis secundaria a la invasion parasitaria. Otra de las entidades es la ehrlichiosis, caracterizada por la infeccion de microorganismos intracelulares cuyos sintomas hacen parte del espectro de un cuadro febril. Caso clinico: paciente procedente de area rural, con historia de exposicion a ixodoideos (garrapatas) de forma permanente. Ingresa cursando signos de respuesta inflamatoria sistemica, sintomas constitucionales y fiebre de predominio vespertino. Hepatomegalia y adenomegalias en region supraclavicular. Con impresion clinica de cuadro febril prolongado y anemia hemolitica, se solicita extendido de sangre periferica para hemoparasitos. Reporte positivo para dos especies: Babesia spp. y Ehrlichia spp., fueron visualizadas por tincion de Giemsa-Whright. Se realizo tratamiento con doxiciclina, clindamicina y quinina, con buena evolucion clinica. No se presentaron complicaciones. Conclusiones : este es el primer caso de coinfeccion conocido de la region Caribe colombiana. El diagnostico se sospecho debido a la importancia dada a los antecedentes epidemiologicos, a la historia de exposicion a ixodidos y a la clinica de sindrome febril persistente. Este, se realizo bajo tecnica de microscopia por tincion de Wrihgt-Giemsa y el resultado, tras el tratamiento antibiotico conjugado, fue exitoso. Rev.Cienc. Biomed. 2012;3(2): 339-345 PALABRAS CLAVES Hemoparasitos; Coinfeccion; Babesia spp.; Ehrlichia spp.; Fiebre. SUMMARY Introduction: there are multiple entities that are transmitted by ticks; one of them isthe babesiosis, an entity that is produced by species of hemoparasites that produce,in the human host, hemolysis due to the parasitic invasion. Other of the entities is taquicartheehrlichiosis, which is characterized by the infection of intracellular microorganismswhose symptoms are part of the spectrum of a fever pattern. Clinical case: patient from rural area, with history of exposure to ixodoidea (ticks)in a permanent way. Who is admitted with signs of systemic inflammatory response,constitutional symptoms and fever of evening predominance. Hepatomegaly andadenomegalies in supraclavicular area were found. With clinical impression of prolongedfever pattern and hemolytic anemia; it was asked for spread of peripheral blood forhemoparasites. Positive report for two species: Babesia spp. and Ehrlichia spp whichwere visualized by Wright-Giemsa stain. It is carried out treatment with doxycycline,clindamycin and quinine, with good clinical aspects. Without any complications. Conclusions: this is the first case of co-infection that is known in the ColombianCaribbean region, the diagnosis was suspected due to the importance that was givento the epidemiological antecedents, to the history of exposure to ixodoidea and to theclinical symptoms of persistent fever syndrome. It was done under microscopy techniqueby Wright-Giemsa stain and the result after the conjugated antibiotic treatment wassuccessful. Rev.Cienc.Biomed. 2012;3(2):339-345. KEYWORDS Hemoparasites; coinfection; Babesia spp.; Ehrlichia spp.; Fever.