Artificial heart valves are used to replace diseased heart valves [1]. Accurate performance of the valve includes a right opening and closing process of the valves during each heartbeat. Recent studies focus on 3D computational models for commercial valvular prosthesis in non-stationary conditions for non-Newtonian Fluids [2]. However, lifespan of mechanical valves needs to be improved. The main goal of this study was to evaluate three novel geometries for mitral valve replacement using computational fluid dynamics (CFD). Our findings show that cylindrical trileaflet valve has the best performance and could be suitable for mitral valve replacement.