This study aimed to evaluate the Quantitative Ultrasound (QUS) on a group of women with and without fractures, and to assess whether there was any difference between the right and the left foot in the first and second measurements of each foot.A total of 52 women, 26 with and 26 without fractures, matched by age (± 2 years), years since menopause (± 2 years), and body mass index (kg/m 2 ) (± 2) were evaluated.The results were compared by the Student's t test for matched samples, and the Wilcoxon test when necessary.The values (mean ± SD) for the stiffness index (SI) were 54.9 (± 16.6) and 80.4 (± 17.3), and the T score were -2.9 (± 0.94) and -1.3 (± 0.95) for the groups with and without fractures, respectively.The first and second measures of the SI for the right foot were found similar, and the mean measure of each foot was also found similar when compared to one another (p = 0.51).In conclusion, the QUS was able to discriminate between women with and without fractures.Also, in the studied women, no differences were observed on the QUS of the left or right foot, nor in the first or second measures of each foot.Further studies with a large number of cases are necessary in order to confirm these results.