Hydrodynamic screws could be an interesting alternative for low-head hydropower generation in Colombia, due to the simplicity of their use in civil works and their reduced environmental impact.This study aims to determine the technical and economic feasibility of hydrodynamic screws for power generation in Colombia, taking El Chuscal Creek (located in eastern Antioquia) as a case study.The site selected for the designs and analysis is representative of the Colombian mountain topography.In order to determine the technical feasibility, parameters such as geometrical design, site topography and hydrology are characterized.The economic viability considers the cost of the screw and the generator, the civil works and the maintenance required.A financial flow is constructed to conceptually evaluate the project.These projects could be implemented in the country with small environmental impacts, as there is very small alteration of sediment dynamics.In the current market and considering regulatory conditions, it is unlikely that these projects are feasible for grid generation, but they could be an interesting alternative for self-consumption.Changes in regulatory conditions and technological advancements (like smart grids) could make these projects competitive.