Introduction: Despite the high prevalence of asthma, there is no consensus in the literature regarding non-drug methods for thetreatment of their symptoms. Thus, holistic therapies such as osteopathy can be viable alternatives since evidence has shown benefits ofosteopathic manipulative treatment of clinical conditions such as asthma. Objective: To gather evidence tested osteopathic approach totreating the symptoms, respiratory dysfunction, medication use and quality of life of patients with asthma. Method: Electronic searcheswere conducted between October and November 2014. It was used as descriptors crossed, or alone in the fields “words”, “subjectdescriptors”, “title words”, “title” and “abstract” the following keywords combined with Boolean operators AND and OR: OsteopathicMedicine, osteopathic manipulation, osteopathy, Spinal Manipulation, Manual Therapy, Therapy Skull Sacral, Chiropractic, ChiropracticManipulation, Asthma. Initially they were collected all the articles that addressed the manual features used by osteopathic or chiropracticcorrelated with the asthma treatment published between 1998 and 2014. Results: It was found 35 articles, of which 28 were excludedbecause they did not conform to pre-defined criteria. Thus, seven works were part of this review. Four of them are clinical trials, twocase studies and a pilot study. Conclusion: Our findings suggest that osteopathic manipulative techniques can be used as non-medicatedadditional resource in the treatment of patients with asthma. The reviewed studies have identified improving the quality of life, subjectiveperception of symptoms and reduce the use of drugs.