attempts to find a response tothe use of hydroxyethyl starch (HES) 6% in surgical patientsand its possible connection with an increase in mortality at30 days (primary outcome), the appearance of acute kidneyinjury (AKI) and the need for dialytic support. These aspectsare associated with patients in intensive care, especially withsepsis. To do this, they designed a systematic review of litera-ture since 1946, choosing those essays that compared HES 6%with otherresuscitationsolutions.Finally,theselected19ran-domized clinical studies, obtaining 1567 patients with whomthey carried out a meta-analysis.No differences were found in surgical patients or in mor-tality betweentheuseofHES6%andofothertypesoffluidsinterms of mortality — RD 0.00, CI 95%: 0.02–0.02 — or the need