Objective: Determine the effect of mood, anxiety and depression on sexual health and the impact on colombian women who have undergone treatment for breast cancer. Methods: cross-correlational design, non-probability sampling, sample 103 women undergoing treatment for breast cancer. Sexual Function Questionnaire – SFQ Karen Syrjala, 2000), Profile of mood – POMS, anxiety and depression inventory of Beck was applied. Results: The impact of treatment in breast cancer is affected by anxiety and depression experienced by women undergoing these treatments. Also, it is negatively related to sexual health in the dimensions excitement, activity, desire, satisfaction, orgasm, relationships and interest, and the mood in the vigor subscale. In contrast, the mood affects both sexual health as the impact of treatment. Conclusions: It contributes to knowledge about sexual and emotional health facing women as a result of the effects of treatments for breast cancer and provides the basis for nursing development, implementation and measurement of interventions to mitigate the impact of the treatments.