This paper presents an analysis of the structural capital inside research and development groups (R & D) in public universities in Colombia. The study is mainly based on Sveiby (1997), (Snell et al, 1999), Obeso (1999), Teece (2000), Lev (2001), CIC (2003), Ordonez (2004), Bontis (2004), Bueno (2005), Simo and Sallan (2008), Andriessen (2008), Alama (2008), Molina (2009), Paździor and Paździor (2012), Bratianu and Orzea (2013) and Bratianu (2014). They point out the intellectual capital as a critical productions factor and competitiveness generator. Similarly, they classified the capital in three components: human, structural and relational. The authors are agreed with Bratianu (2014), and his conception of intellectual capital and entropic dynamic. The structural capital is no longer potential; it is in the operational phase. The structural capital’s fundamentals of CIC (2003) divided into organizational and technological were considered. The research is descriptive with a field design, non-experimental and transactional. A Likert scale questionnaire is used to measure the R & D groups. The results show as strengths, the efforts in R & D, and technological attempts. In other hand, the weaknesses are associated with intellectual property and innovation performance. So, the groups create management models for monitoring and improve the knowledge protection and metrics results. The models go through innovative strength indicators related to the amount of innovation, effectiveness, relating benefits versus resources, innovation culture and economic indicators.