The present exploratory study is an initial effort to understand marriage and family therapists’ perceptions regarding women’s depression and preferred treatments in the United States and six other countries—China, Colombia, India, Indonesia, Iran, and the Philippines. With this aim, an online survey was completed by 87 U.S. therapists and 79 non-U.S. therapists. We analyzed the data through multiple t-tests for independent samples. Statistical comparisons of the responses indicated (a) U.S. therapists perceived it was more acceptable for women to talk about feeling depressed than non-U.S. therapists, (b) non-U.S. therapists perceived it was more frequent for women to present with somatic symptoms when depressed than U.S. therapists, (c) non-U.S. therapists reported using individual treatment for women’s depression more frequently than U.S. therapists, (d) U.S. therapists reported using couple or family therapy to treat women’s depression more frequently than non-U.S. therapists, and (e) U.S. therapists perceived husbands and male partners were open to participate in women’s therapy for depression more frequently than non-U.S. therapists. We discuss the clinical and research implications of our findings.