Cinturón Andino is the largest biosphere reserve of Colombia, located in the southernmost region of the state, the so-called Macizo Colombiano. For years threatened by guerilla activities and internal conflicts between indígenas and campesinos, the farmers have now initiated new attempts to adapt to climate change, to implement organic farming in order to secure the water quality and supply for the large cities in the vicinity of the park, to improve their livelihood and to strengthen the social and human capital. This article describes the chosen path to sustainability and provides suggestions for the adaptation of the park to the UNESCO Seville Strategy for biosphere reserves.