The title compound 1,4-di(2-butoxycarbonyl-trans-vinyl)-2,5-dimethoxybenzene was synthesized in 94% yield through the Heck reaction between 2,5-diiodo-1,4-dimethoxybenzene and n-butyl acrylate, using bis(dibenzylideneacetone) palladium(0) as homogeneous catalyst.