The continuous enantioselective hydrogenation of ethyl pyruvate (EP) in a continuous flow reactor at 25ºC on 1%Pt-CD/SiO 2 catalysts has been studied.The catalytic study included the analysis of variables such as: particle size, feed flow, H 2 pressure and the addition of chiral modifier to the reactor feed.The catalysts were prepared using impregnation of Pt colloids which are stabilized with different quantities of cinchonidine (CD) on SiO 2 .This process gives chiral properties to the catalyst and allows changing the particle size for the reaction of interest.The catalysts were characterized by adsorption/desorption isotherms of N 2 a 77 K, TEM, XPS and the analysis of products by GC-MS.The monitoring of the reaction indicates a significant increases in the conversion when decreasing the contact time and a maximum in the enantiomeric excess (ee) of 63 % to the (R)-ethyl lactate which is obtained after using 200mg of 1%Pt/SiO 2 catalyst (1.6nm) at 10 bar of H 2 and a flow of 0.3 mL/min of a mixture EP (0.01M) and CD (0.034M) in cyclohexane.