The objective of this study was to explore the contributions of personality traits, self-efficacy, and interests to the high and low academic performance of adolescent students in different areas of knowledge. Through the implementation of a discriminant analysis, the results of the study show that the three measurements under consideration contribute significantly to the explanation of 23% to 50% of academic performance, depending on the domain. The information gathered is expected to help researchers and professionals in the field of education understand the psychological pattern that facilitates academic success.