Structured Abstract Authors – Rossouw PE, Buschang PH The objective of the study was to provide insight into clinical and laboratory aspects of mini‐screw implant (MI) research conducted in the Department of Orthodontics at Baylor College of Dentistry. Excerpts were selected from clinical and laboratory MI research utilizing one type of implant and one consistent placement protocol to illustrate the clinical usage of MI as skeletal anchorage during Class II bimaxillary correction. In addition, a translational animal model was utilized to illustrate possible side‐effects of MI placement. Our studies have shown that successful and consistent clinical results are possible with MI use. Although iatrogenic trauma may occur during the placement of MI, a translational research model has provided data used to develop a placement protocol in order to avoid this dilemma. Absolute skeletal anchorage is a reality with MI use and can be used for successful orthodontic outcomes in the correction of Class II bimaxillary protrusion malocclusions to ideal Class I occlusions. Moreover, meticulous care has been shown to be essential with treatment planning and during placement of MI. Significant and extensive damage can occur with poor placement while healing is possible following minor trauma.