The current study aims to (1) determine whether there is a relationship between the problems of patients with dementia and the psychosocial functioning of the caregiver, (2) determine whether these relationships exist independent of sociodemographic and caregiving-related variables, and (3) determine which type of problems of patients with dementia best predict the psychosocial functioning of the caregiver. In all, 73 family caregivers were recruited from Bogota, Colombia. The caregivers completed a checklist of problems presented by the person with dementia, Patient Health Questionnaire (PHQ-9), Zarit Burden Interview (ZBI), Interpersonal Support Evaluation List (ISEL-12), and Satisfaction with Life Scale (SWLS). Number of cognitive and behavioral/emotional problems presented by the person with dementia was positively correlated with caregiver PHQ-9 and ZBI scores. Number of behavioral/emotional problems was negatively correlated with ISEL-12 scores. Cognitive and behavioral/emotional problems, but not physical, presented by the person with dementia were associated with higher levels of depression and burden of caregiver. Behavioral/emotional difficulties were associated with lower caregiver-perceived social support rating.