Möbius syndrome is a congenital paralysis of the seventh cranial nerve that may be associated with involvement of other cranial nerves or other systems.In the United States frequencies from 0.002 to 0.0002 % of all births, and 1/ 50 000 newborns have been calculated.The aim of the study was to present a case of a newborn with Möbius syndrome prenatally exposed to Misoprostol, detected in a third level hospital, under the parameters of the Latin American Collaborative Study of Congenital Malformations (ECLAMC).Literature search focused on the association of prenatal exposure to Misoprostol and congenital malformations, was realized.Case Presentation: Newborn with phenotypic characteristics of Möbius syndrome, 16 -year-old mother with history of use of Misoprostol 200 mcg vaginally and 200 mcg orally during the fourth week of gestation.Discussion: Facial palsy and congenital musculoskeletal anomaly have to be established in order to diagnose Möbius syndrome, the patient meets both.Prenatal exposure to Misoprostol has been associated with the occurrence of birth defects, mainly Möbius syndrome and limb defects of terminal transverse type.One of the teratogenic mechanisms proposed for Misoprostol is vascular disruption, as we propose it could be in this case.