The consideration of temporal lobe epilepsy (TLE) surgery for those with medically refractory seizure disorders requires a well-functioning multidisciplinary team and a systematic approach to the candidates, with the aim of advising patients of their chances of being seizure free following surgery, and the risks of any procedure. It is crucial that patients and their families are given realistic expectations of what may and may not be achieved with surgical treatment, and that long-term follow-up is maintained postoperatively. Complex partial seizure (CPS) of temporal lobe is the most common type of seizure disorder, and approximately 70% of patients are referred for surgical treatment. In this chapter we want to discuss the different forms of presurgical evaluation and patient selection. The patients that are considered as possible candidates for epilepsy surgery, need to have a detailed clinical history and demonstration of drug resistant-epilepsy. We assume that the issues about clinical history have been mentioned in previous chapters, so our approach will start from the identification of the epileptogenic zone (I. Irritative zone, II. Seizure-onset zone, III. Symptomatogenic zone, IV. Epileptogenic lesion and V. Functional deficit zone) and patient selection using different diagnostic techniques, that include: • Semiology • Neurophysiological criteria • Neuropsychological evaluation • Intracarotid Amobarbital Procedure (IAP), and • Neuroimaging