This paper presents a hybrid of artificial neural networks and artificial bee colony algorithm to optimize the process parameters in injection molding with the aim of minimize warpage of plastic products. A feedforward neural network is employed to obtain a mathematical relationship between the process parameters and the optimization goal. Artificial bee colony algorithm is used to find the optimal set of process parameters values that would result in the optimal solution. An experimental case is presented by coupling Moldflow simulations along with the intelligent schemes in order to validate the proposed approach. Melt temperature, mold temperature, packing pressure, packing time, and cooling time are considered as the design variables. Results revealed the proposed approach can efficiently support engineers to determine the optimal process parameters and achieve competitive advantages in terms of quality and costs.