It is not fully understood whether masticatory performance is compromised in individuals with the more common forms of malocclusion (i.e. Class I and Class II). The aim of this prospective investigation was to establish the relationships between masticatory performance, malocclusion (type and severity), age, body size and gender, in children and adolescents. A total of 335 individuals were examined at the average ages of 6, 9, 12 and 15 years. Each subject's occlusal status was described by Angle classification and by the Peer Assessment Ratio (PAR) index. Masticatory performance was quantified by the median particle size (MPS) and the broadness of particle distribution using artificial food.