In this paper, a 4 times 4 indoor multiple-input multiple-output (MIMO) measurement campaign at a frequency of 2.45 GHz is presented. The main contribution of this work is the analysis of the impact of radio-wave polarization in MIMO systems operating at a typical indoor scenario through the calculation-from the measurements carried out-of a great deal of parameters such as the mean path loss, the cross polarization discrimination (XPD), and the RMS delay spread, which are all essential to estimate the performance of real MIMO systems. In this sense, some path loss models-which have been adjusted according to the measurements-are given, taking into account polarization, attenuation through walls, and the effect of T-junctions existing in the considered indoor scenario. Moreover, additional parameters such as the K-factor and statistical distribution, as well as spatial parameters, are discussed.