Ascariasis and trichuriasis are highly prevalent parasitoses in tropical countries caused by Ascaris lumbricoides and Trichuris trichiura, respectively. Their prevalence is associated with poor sanitation and hygiene, among other biological and social factors. In this study, the associations of household social determinants with these soil-transmitted helminthiases in North Central Venezuela was assessed in the context of a National Study on Human Growth and Development (SENACREDH). This was a probabilistic, stratified, cross-sectional survey with a sample of 3388 individuals that weighted represents 4 675 433 inhabitants from the region. The prevalence of ascariasis and trichuriasis was 3.73% and 1.13%, respectively. In the univariate and multivariate analyses, these prevalences were significantly higher in those living in vulnerable houses [adjusted OR (AOR) = 1.479, 95% CI 1.428–1.532; and AOR = 10.519, 95% CI 9.971–11.097, respectively], houses located in rural areas (AOR = 2.067, 95% CI 2.035–2.101; and AOR = 1.918, 95% CI 1.868–1.970, respectively) and houses with a soil floor (AOR = 5.027, 95% CI 4.895–5.162; and AOR = 5.190, 95% CI 4.944–5.448, respectively), among other factors. People living in rural households with inappropriate building materials, insufficient basic public services such as water and waste disposal, and surrounding disease-prone environments are at higher risk of acquiring A. lumbricoides and T. trichiura infections.