In this paper, we deal with the polyhedral description and the resolution of the Mixed General Routing Problem. This problem, in which the service activity occurs both at some of the nodes and at some of the arcs and edges of a mixed graph, contains a large number of important arc and node routing problems as special cases. Here, a large family of facet-defining inequalities, the Honeycomb inequalities, is described. Furthermore, a cutting-plane algorithm for this problem that incorporates new separation procedures for the K-C, Regular Path-Bridge, and Honeycomb inequalities is presented. Branch and bound is invoked when the final solution of the cutting-plane procedure is fractional. Extensive computational experiments over different sets of instances are included.