The combined effects of hydrostatic pressure, temperature, and aluminum concentration on the binding and total energies of two coupled donors are analyzed using a variational procedure. The effects of changing the nucleus–nucleus relative positions and the quantum well size on the complex binding energy were also analyzed. The results show that an increase in the temperature yields a decrease of the binding energy while an increase in the aluminum concentration or hydrostatic pressure, enhance the binding energy favoring the stability of molecular complex under strong quantum confinement conditions.