The evolution of medicine during the past century has shown important scientific, technological, surgical, pharmacological and anesthetic breakthroughs that have enabled various types of procedures for our patients, consistently aiming at providing the best comfort and the highest safety standards. In our daily practice, in addition to the procedures performed under general and regional anesthesia (regional blocks and peripheral nerve blocks) we do some procedures under Sedation (with or without local anesthesia), both in the operating theater or outside, and even in environments outside hospitals. This fact has resulted in an exponential increase in the number of therapeutic and diagnostic procedures in various healthcare areas, including dentistry, maxillofacial surgery, pediatric dentistry, peripheral vascular surgery, gastroenterology, fertility, and diagnostic imaging, inter alia. At our institutions we perform anesthetic techniques that ensure the right conditions for various surgical procedures such as regional blocks (subarachnoid and epidural) and peripheral nerve blocks that are useful and safe for various types of surgeries; unfortunately, there are some drawbacks in the use of regional anesthesia: puncture site pain, fear of needles, and procedure memories. These factors emphasize the importance of sedation obtained from analgesia, anxiolysis, and amnesia that enable a seamless development of the technique.1