We present a series of paleontological, archaeological and legend-based evidence that suggests to us that the American bison could have coexisted in some refugia with the Amerindians in Central America until as recently as 150 A.D. The aforementioned brings to light the presence of the American bison, the largest extant mammal on the con- tinent, as a possible new source of diet and clothing during the Holocene, which should be considered as a possibility on the list of megamammals that were potentially hunted on the Central American savannahs.