Objective: To determine the effectiveness of the median nerve glide for treatment of carpal tunnel syndrome. Search methods: A systematic review of the CENTRAL, MEDLINE, EMBASE, CINAHL, and PEDro data bases was conducted. The search included randomized, controlled trials with adult patients diagnosed of carpal tunnel syndrome. Studies published from January 2000 to February 2012 were included.Results of the search: Thirteen articles were located and reviewed. Finally, 6 studies that met the inclusion criteria of this study were analyzed. The neural glide techniques, conservative treatments (ultrasound, paraffin, tendon glide) and splinting were compared. Conclusions: There is moderate evidence supporting the use of median nerve glide techniques for the treatment of carpal tunnel syndrome.