HLA‐G non classical class I locus shows a comparatively low polymorphism. It encodes for tolerogenic HLA molecules that may be important in autoimmunity and transplant (and foetal) rejection control. HLA‐G molecules give negative signals to Natural Killer and T lymphocytes. In the present paper, a new allele, HLA‐G*08, is described, which may be useful for monitoring transplants and for HLA and disease studies.