Two new coumarin compounds (1 and 2), phebalosin (3), its derived artifact murralongin (4), and murrangatin acetonide (5) were isolated from the leaves of Galipea panamensis. The structures of 1 and 2 were assigned as 7-{[(2R*)-3,3-dimethyloxiran-2-yl]methoxy}-8-[(2R*,3R*)-3-isopropenyloxiran-2-yl]-2H-chromen-2-one and 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, respectively, on the basis of their spectroscopic data (primarily NMR and MS). Compounds 1−3 were tested against axenic amastigote forms of Leishmania panamensis and displayed 50% effective concentrations (EC50) of 9.9, 10.5, and 14.1 μg/mL, respectively. These three compounds also displayed cytotoxicity (IC50) at concentrations of 9.7, 33.0, and 20.7 μg/mL, respectively, on human promonocytic U-937 cells.