The thermodynamic functions of Gibbs energy, enthalpy, and entropy for the solution processes of triclosan (TS) were calculated from solubility values obtained at the temperature interval from (293.15 to 313.15) K. TS solubility was determined in ethanol (EtOH), octanol (ROH), isopropyl myristate (IPM), chloroform (CLF), and heptane (HPT) as pure solvents. The excess Gibbs energy and the activity coefficients of the solutes were also calculated. The TS solubilities were higher in EtOH and CLF with respect to those obtained in ROH, IPM, and HPT. In addition, the thermodynamic quantities relative to the transfer process of this drug from HPT to the other organic solvents were also calculated to estimate the hydrogen bonding contributions.