This paper describes how enterprise integration engineering (EIE) and action-research (A-R) can be used to support the implementation of product lifecycle management (PLM) tools. The EIE concept is used to align the corporate strategies with the use of PLM technologies in order to impact the key performance indicators (KPIs) in the enterprise. An EIE reference framework is proposed to define strategies, evaluate performance measures, design/re-design processes and establish the enabling tools and technologies to support the enterprise strategies, while A-R is proposed to guide the PLM tools implementation at various stages of the product development process. An industrial application is described to demonstrate the benefits of applying EIE, A-R and PLM in an enterprise.