This research was developed with aim to determine the prevalence of non-compliance or non-adherence to drug treatment and the latter's association with the intrinsic and extrinsic determinants of tuberculosis patients of the Health Center Manuela Beltran. Adherence was determined by validated Morisky-Greem-Levine test and the association by chi - square test of independence and Fisher exact test, the factors considered statistically significant were those that had a p-value < 0.05. Therapeutic failure patients was 81.8 % (95% CI 70-94 %). Of the factors that were the only statistically significant associations were related to the health care team, including these recommendations on drug treatment service delivered by the pharmacist and physician receptivity regard to patient questions and comments (p-value of 0.029 and 0.004, respectively). The prevalence of non-compliance with drug therapy of patients was very high and associated factors related to care and quality of services provided by the health team impact the motivation, confidence and use of pharmacotherapy.